期刊
APPLIED PHYSICS LETTERS
卷 95, 期 14, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3226103
关键词
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资金
- Ontario Centres of Excellence, Genome Canada
- Ontario Ministry of Research and Innovation
- NSERC [484838]
We report an integrated chip that senses nucleic acid biomarkers at exceptionally low concentrations. To achieve such sensitivities we exploit four concepts. (1) Nanostructured electrodes allow efficient display of probe sequences. (2) The use of uncharged probe sequences lowers the background signal in our read-out system. (3) Electrocatalysis provides built-in amplification of the electrical signal that reports hybridization events. (4) An optimal self-assembled monolayer of thiol-functionalized probe molecules is best achieved with the aid of a short spacer molecule to confer enhanced accessibility. We show herein that via joint optimization along these four axes we achieve attomolar sensitivity. (C) 2009 American Institute of Physics. [doi:10.1063/1.3226103]
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