4.5 Article

FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of sprouty and suppression of ERK activity

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JOURNAL OF CELL SCIENCE
卷 117, 期 25, 页码 6007-6017

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COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.01519

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FGFR; FRS2; sprouty; SRC; ERK

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Activation of signalling by fibroblast growth factor receptor leads to phosphorylation of the signalling attenuator human Sprouty 2 (hSpry2) on residue Y55. This event requires the presence of the signalling adaptor fibroblast growth factor receptor substrate 2 (FRS2). The phosphorylation of hSpry2 is therefore mediated by an intermediate kinase. Using a SRC family kinase-specific inhibitor and mutant cells, we show that hSpry2 is a direct substrate for SRC family kinases, including SRC itself. Activation of SRC via fibroblast growth factor signalling is dependent upon FRS2 and fibroblast growth factor receptor kinase activity. SRC forms a complex with hSpry2 and this interaction is enhanced by hSpry2 phosphorylation. Phosphorylation of hSpry2 is required for hSpry2 to inhibit activation of the extracellular signal-regulated kinase pathway. These results show that recruitment of SRC to FRS2 leads to activation of signal attenuation pathways.

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