期刊
JOURNAL OF DENTAL RESEARCH
卷 83, 期 12, 页码 909-913出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/154405910408301204
关键词
enamelysin; amelogenin; amelogenesis; FTIR; microhardness
资金
- NIDCR NIH HHS [DE14084, R01 DE014084, DE13237] Funding Source: Medline
During enamel development, matrix metalloproteinase-20 (MMP-20, enamelysin) is expressed early during the secretory stage as the enamel thickens, and kallikrein-4 (KLK-4, EMSP1) is expressed later during the maturation stage as the enamel hardens. Thus, we investigated whether the physical properties of the secretory/ maturation-stage MMP-20 null enamel were significantly different from those of controls. We demonstrated that although, in relative terms, the weight percent of mature mineral in the MMP-20 null mouse enamel was only 7-16% less than that in controls, overall the enamel mineral was reduced by about 50%, and its hardness was decreased by 37%. Percent mineral content by weight was assessed at 3 different developmental stages. Remarkably, the biggest difference in mineral content between MMP-20 null and controls occurred in the nearly mature enamel, when MMP-20 is normally no longer expressed. This suggests that MMP-20 acts either directly or indirectly to facilitate the removal of maturation-stage enamel proteins.
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