期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 8, 期 6, 页码 515-519出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.8.6.515
关键词
antibiotics; methicillin-resistant Staphylococcus aureus (MRSA); novel agents; resistance emergence; therapy
Methicillin-resistant Staphylococcus aureus (MRSA) is a serious nosocomial pathogen, and a related community-sourced MRSA is emerging. MRSA has evolved to become the major S. aureus phenotype in the hospital, emerging from just 30 to over 60% of the S. aureus population over the past 15 years. Together with its beta-lactam resistance, MRSA possesses multi-drug resistance genotype, including quinolones, macrolides and sulfonamides. MRSA has now emerged as the predominant nosocomial Gram-positive pathogen, and it has a high rate of mortality. Action must be taken to contain and eradicate MRSA through a combination of infection control and the development of novel anti-MRSA agents and vaccines.
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