期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 14, 期 6, 页码 656-662出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2004.10.007
关键词
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资金
- NIGMS NIH HHS [GM-66569] Funding Source: Medline
For several decades, single-crystal microspectrophotometry has contributed to structural enzymology as a very useful complement to X-ray crystallography. In its most recent applications, it is the ideal tool to track chemistry as structure evolves in the course of time-resolved experiments, to identify freeze-trapped catalytic intermediates and to assess radiation-induced effects on enzyme crystals. To these goals, instruments have been developed to record optical spectra 'on-line' in the course of X-ray data collection, whereas more rigorous polarized absorption studies 'off-line' play an essential role in describing what protein function is retained in the crystalline state and correlating it with the observed structures.
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