期刊
GENE EXPRESSION PATTERNS
卷 5, 期 2, 页码 257-263出版社
ELSEVIER
DOI: 10.1016/j.modgep.2004.07.008
关键词
ovary; testis; oocyte; HORMA domain; germ cell; Nohma
资金
- NICHD NIH HHS [HD42500, HD33438, HD01426, HD00849, HD007165] Funding Source: Medline
HORMA-domain containing proteins are involved in cell cycle regulation by interactions with chromatin. Through an in silico subtractive screen for mouse genes preferentially expressed in newbom ovaries, we identified a gene that would encode a novel mammalian HORMA domain-containing protein termed Newborn Ovary HORMA protein (Nohnna). Reverse transcription polymerase chain reaction and Northern blot analysis have demonstrated a 1.7 kb transcript that is expressed exclusively in germ cells in both male and female mouse gonads. Nohma expression can be detected postnatally in male, and prenatally in female gonads, but shows a sexually dimorphic expression in adult gonads. The Nohma transcript is abundant in the adult testis but limited in the adult ovary. The mouse Nohma gene is comprised of 15 exons and maps to chromosome 3. A human ortholog was also identified. The expression pattern of Nohma suggests that it may be a critical regulatory protein in germ cell meiosis. (C) 2004 Elsevier B.V. All rights reserved.
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