期刊
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
卷 19, 期 -, 页码 S79-S81出版社
WILEY
DOI: 10.1111/j.1440-1746.2004.03634.x
关键词
non-responders; retreatment of chronic hepatitis C virus; thymalfasin; triple therapy
Despite steady progress in antiviral treatment for patients with chronic hepatitis C virus (HCV), many patients still have detectable serum HCV RNA levels by the end of interferon-based treatment and are known as virological non-responders. Re-treatment of these patients not responding to previous therapy remains challenging. Studies of the dynamics of the HCV population show a marked decline in new cases since 1996; however, the relative proportion of non-responders is expected to increase over time and, similarly, the number of patients eligible for first-line treatment is expected to decrease. The current standard of care for treatment involves the use of pegylated interferons in combination with ribavirin. However, many difficult-to-treat groups still have low response rates. Newer combinations are being investigated to optimize chances of attaining a sustained response in these groups: one such triple therapy regimen is peginterferon alfa-2a, ribavirin and thymalfasin, which was given to 23 previously non-responder patients. Viral response was 60.8% at week 12 and 47.8% at week 24. These preliminary results encourage further evaluation of this promising combination. (C) 2004 Blackwell Publishing Asia Pty Ltd.
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