期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 97, 期 6, 页码 2214-2219出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00491.2004
关键词
IL-15; strength; skeletal muscle; muscle quality
资金
- NIAMS NIH HHS [5 P20 AR44811-04] Funding Source: Medline
- NIA NIH HHS [AG-05893, AG-022791] Funding Source: Medline
- NIDDK NIH HHS [DK-45204, P30-DK046204] Funding Source: Medline
Interleukin-15 (IL-15) is an anabolic cytokine that is produced in skeletal muscle and directly affects muscle anabolism in animal and in vitro models. The contribution of IL-15 variability in muscle responses to 10 wk of resistance exercise training in young men and women was examined by measuring acute and chronic changes in IL-15 protein in plasma and characterizing genetic variation in the IL-15 receptor-alpha gene ( IL15RA). Participants trained 3 days a week at 75% of one repetition maximum, performing three sets ( 6 - 10 repetitions) of 13 resistance exercises. Plasma IL-15 protein was significantly increased ( P < 0.05) immediately after acute resistance exercise but did not change with training and was not associated with variability in muscle responses with training. A single nucleotide polymorphism in exon 7 of IL15RA was strongly associated with muscle hypertrophy and accounted for 7.1% of the variation in regression modeling. A polymorphism in exon 4 was also independently associated with muscle hypertrophy and accounted for an additional 3.5% of the variation in hypertrophy. These results suggest that IL-15 is an important mediator of muscle mass response to resistance exercise training in humans and that genetic variation in IL15RA accounts for a significant proportion of the variability in this response.
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