期刊
ADVANCES IN PHYSIOLOGY EDUCATION
卷 28, 期 4, 页码 155-159出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/advan.00034.2004
关键词
osmosis; cell volume regulation; organic osmolytes; membrane transport; signal transduction
All cells face constant challenges to their volume either through changes in intracellular solute content or extracellular osmolality. Cells respond to volume perturbations by activating membrane transport and/or metabolic processes that result in net solute loss or gain and return of cell volume to its normal resting state. This paper provides a brief overview of fundamental concepts of osmotic water flow across cell membranes, mechanisms of cell volume perturbation, the role of inorganic ions and organic osmolytes in cell volume regulation and the signaling mechanisms that regulate the activity of cell volume-sensitive transport and metabolic pathways.
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