期刊
APPLIED PHYSICS LETTERS
卷 93, 期 22, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3036898
关键词
biomagnetism; biomedical measurement; bioMEMS; blood; cellular biophysics; ferromagnetic materials; magnetic fields; magnetic separation; microchannel flow
资金
- Korea Research Foundation
- Korean Government [KRF-2008-331-D00771]
- Korea Science and Engineering Foundation (KOSEF)
- Korean Government (MEST) [R01-2008-000-20238-0]
- National Research Foundation of Korea [R01-2008-000-20238-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We present a method for the lateral-driven continuous magnetophoretic separation of red and white blood cells from peripheral whole blood, based on their native magnetic properties. The separation is achieved using a high-gradient magnetic field, caused by a ferromagnetic wire array inlaid on glass substrate. The wire array creates an even lateral magnetophoretic force on the whole area of the microchannel, improving the separation efficiency and throughput. When the flow rate and external magnetic flux were 20 mu l/h and 0.3 T, respectively, the microseparator continuously separated out 93.9% of red blood cells and 89.2% of white blood cells from the whole blood.
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