期刊
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
卷 27, 期 6, 页码 455-466出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1111/j.1365-2885.2004.00604.x
关键词
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Bioavailability is a key pharmacokinetic parameter which expresses the proportion of a drug administered by any nonvascular route that gains access to the systemic circulation. Presented in this review are the different approaches to measurement of bioavailability (absolute and relative), including the case in which intravenous administration is impossible. The rate of drug absorption is also discussed with special emphasis on the possible difficulties encountered using C-max and T-max or curve fitting to evaluate the rate of drug absorption.
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