期刊
AIDS RESEARCH AND HUMAN RETROVIRUSES
卷 20, 期 12, 页码 1377-1381出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2004.20.1377
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资金
- NIAID NIH HHS [P30 AI027767-099004, P30 AI027767-14S19004, P30 AI027767-169004, P30 AI 27767, P30 AI027767-119004, R13 AI058790, R01 AI050529-02, R01 AI058715-02, R01 AI044596, R01 AI050529-03, P30 AI027767-139004, R01 AI058715-05, N01AI85338, R01 AI50529, P30 AI027767, N01 AI085338-002, N01 AI85338, R01 AI050529-01, R01 AI058715, R01 AI050529-05, R01 AI058715-01, P30 AI027767-159004, P30 AI027767-149004, R01 AI050529-06A1, R01 AI058715-03, R01 AI050529, P30 AI027767-169007, R01 AI58715, P30 AI027767-129004, R01 AI058715-04, R01 AI050529-04, R01 AI44596, R13 AI058790-01] Funding Source: Medline
Chimpanzees in west central Africa ( Pan troglodytes troglodytes) are known to harbor simian immunodeficiency viruses (SIVcpzPtt) that represent the closest relatives of human immunodeficiency virus type 1 (HIV-1); however, the number of SIVcpzPtt strains that have been fully characterized is still limited. Here, we report the complete nucleotide sequence of SIVcpzGAB2, a virus originally identified in 1989 in a chimpanzee ( P. t. troglodytes) from Gabon. Analysis of this sequence reveals that SIVcpzGAB2 is a member of the SIVcpzPtt group of viruses, but that it differs from other SIVcpzPtt strains by exhibiting a highly divergent Env V3 loop with an unusual crown (NLSPGTT) containing a canonical N-linked glycosylation site, an unpaired cysteine residue in Env V4, and two late (L) domain motifs (PTAP and YPSL) in Gag p6. Moreover, phylogenetic analyses indicate evidence of recombination during the early divergence of SIVcpzPtt strains; in particular, part of the pol gene sequence of SIVcpzGAB2 appears to be derived from a previously unidentified SIVcpz lineage ancestral to HIV-1 group O. These data indicate extensive diversity among naturally occurring SIVcpzPtt strains and provide new insight into the origin of HIV-1 group O.
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