A new precursor for the preparation of 6-[18F]fluoro-L-m-tyrosine ([18F]FMT):: efficient synthesis and comparison of radiolabeling

For the electrophilic preparation of 6-[F-18]fluoro-L-m-tyrosine ([F-18]FMT), a PET tracer for measuring changes in dopaminergic function in movement disorders, a novel precursor, N-(tert-butoxycarbonyl)-3-(tert-butoxycarbonyloxy)-6-trimethylstannnyl-L-plienylalanine ethyl ester, was synthesized in four steps and 26% yield starting from L-m-tyrosine. [F-18]FIVIT produced by two methods at two institutions was comparable in both radiochemical yield, 25-26%, and quality (chemical, enantiomeric, and radiochemical purity and specific activity) as that obtained with the original N-trifluoroacetyl-3-acetyl-6-trimethylstannyl-L-m-tyrosine ethyl ester [F-18]FMT precursor. (C) 2004 Elsevier Ltd. All rights reserved.