期刊
GENETIC EPIDEMIOLOGY
卷 27, 期 4, 页码 442-450出版社
WILEY-LISS
DOI: 10.1002/gepi.20038
关键词
Hardy-Weinberg tests; composite linkage disequilibrium; inbreeding coefficient; case-control test
资金
- NIGMS NIH HHS [GM 45344] Funding Source: Medline
A dense set of 5,000 SNPs on a 10-Mb region of human chromosome 20 has been typed on samples of African Americans, East Asians, and United Kingdom Caucasians. There are departures from Hardy-Weinberg equilibrium beyond the level at which markers are often discarded because of possible genotyping errors. The observation that markers showing such departures are often close together on the chromosome confirms the result that Hardy-Weinberg tests at two loci are correlated to an extent that depends on the linkage disequilibrium. between those two markers. Linkage disequilibrium can be described by the composite linkage disequilibrium coefficient, the parameter that determines the behavior of case-control allelic tests of association. A useful preliminary investigation of datasets of this type is provided by counting the numbers of distinct multi-locus genotypes in windows of a few markers. Genet. Epidemiol. (C) 2004 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据