期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 42, 期 12, 页码 5885-5888出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.42.12.5885-5888.2004
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资金
- NIAID NIH HHS [N01AI65298, N01-AI-65298] Funding Source: Medline
Using paired serum samples obtained from patients with illness associated with increases in anti-human coronavirus OC43 (HCoV-OC43) or anti-HCoV-229E antibodies, we examined the possibility of false-positive results detected in a recombinant severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) nucleocapsid protein immunoglobulin G enzyme-linked immunosorbent assay (ELISA). Three of the 21 and 1 of the 7 convalescent-phase serum samples from persons with increases in antibodies against HCoV-OC43 and HCoV-229E, respectively, tested positive by the recombinant SARS-CoV nucleocapsid protein-based ELISA. None of these samples were found to contain a specific antibody in the recombinant SARS-CoV spike polypeptide-based Western blot assay.
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