期刊
PLOS BIOLOGY
卷 2, 期 12, 页码 2076-2084出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.0020432
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资金
- NCI NIH HHS [T32-CA09547, T32 CA009547] Funding Source: Medline
- NIAID NIH HHS [R01 AI54483, R01 AI054483, T32 AI007163, T32-AI07163, AI007163] Funding Source: Medline
Noroviruses are understudied because these important enteric pathogens have not been cultured to date. We found that the norovirus murine norovirus 1 (MNV-1) infects macrophage-like cells in vivo and replicates in cultured primary dendritic cells and macrophages. MNV-1 growth was inhibited by the interferon-alphabeta receptor and STAT-1, and was associated with extensive rearrangements of intracellular membranes. An amino acid substitution in the capsid protein of serially passaged MNV-1 was associated with virulence attenuation in vivo. This is the first report of replication of a norovirus in cell culture. The capacity of MNV-1 to replicate in a STAT-1-regulated fashion and the unexpected tropism of a norovirus for cells of the hematopoietic lineage provide important insights into norovirus biology.
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