New camptothecin and ellagic acid analogues from the root bark of Camptotheca acuminata

As part of a study on chemical constituents of Camptotheca species, one new natural camptothecin analogue (2), two new alkaloids (3, 4), one new ellagic acid analogue (5), and 19 known compounds (1, 6-23) have been isolated from the root bark, stem bark, fruits, and leaves of Camptotheca acuminata Decaisne. The structures of 2-5 were determined from spectral data to be 10-methoxy-20-O-acetylcamptothecin (2), 20-O-beta-glucopyranosyl 18-hydroxycamptothecin (3), 20-formylbenz[6,7]indolizino [1,2-b]quino-line-11(13H)-one (4), and 3,4-methylenedioxy-3-O-methyl-5'-hydroxyellagic acid (5).