A novel neurotrophic peptide:: APP63-73

The objective of this study was to find out which N-terminal segment/s of amyloid precursor protein (APP) has any neurotrophic properties, since soluble APP-alpha (sAPP-alpha) has neurotrophic effects. We investigated neurotrophic properties of eight peptide segments of N-terminal APP. The APP(63-73) was able to enhance neuronal growth; augment axonal and cell body growth in human neuroblastoma cell line. SH-SY5Y Neurotrophic effects of chronic APP(63-73) treatment were assessed in vivo using streptozotocin-induced diabetes and ovariectomized rats, Thus, this study demonstrated that APP(63-73) peptide has neurotrophic effects both in vivo and in vitro.