期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 10, 期 23, 页码 5988-5995出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200400390
关键词
chemoselectivity; conjugation; DNA; oligonucleotides; oxime; peptides
A convenient strategy for the synthesis of bifunctionalized oligonucleotide conjugates bearing two different reporters at the 3' and 5' ends of the oligonucleotide is presented. The method involves the preparation of oligonucleotides bearing an aldehyde and/or aminooxy functionality at each end, followed by reaction to form oxime bonds with appropriately functionalized reporters. The conjugation reactions are carried out under mild aqueous conditions with good reaction yield.
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