期刊
NEUROREPORT
卷 15, 期 17, 页码 2659-2663出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200412030-00021
关键词
aging; estrogen; hormone; neurotrophin; progesterone
资金
- NIA NIH HHS [AG 12122, R01 AG010755, R03 AG 023925-01] Funding Source: Medline
- NIDA NIH HHS [P50 DA 16511] Funding Source: Medline
Neurotrophin alterations have, been associated with normal aging and age-related neurodegenerative disease, as well as cognitive status. Estrogen influences expression of mRNA and protein of neurotrophins and their receptors, and affects cognitive performance in young ovariectomized (Ovx) rats. The current investigation evaluated whether estrogen or estrogen plus progesterone affects neurotrophin protein levels in cognitive brain regions in the aged Ovx rat. While estrogen treatment increased BDNF. NGF, and NT3 levels in entorhinal cortex, progesterone abatated the effects of estrogen resulting in neurotrophin levels comparable to aged Ovx rats not given hormone. Our findings suggest that the aged female brain is responsive to estrogen in cognitive brain regions, and that progesterone can reverse these estrogen effects.
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