期刊
VIROLOGY
卷 330, 期 1, 页码 322-331出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2004.09.033
关键词
Severe Acute Respiratory Syndrome (SARS); coronavirus; budding; E protein; ion channel; conductance; Vpu; hydrophobic; monovalent cation; mouse hepatitis virus (MHV)
类别
Severe Acute Respiratory Syndrome (SARS) is caused by a novel coronavirus (SARS-CoV). Coronaviruses including SARS-CoV encode an envelope (E) protein, a small, hydrophobic membrane protein. We report that, in planar lipid bilayers, synthetic peptides corresponding to the SARS-CoV E protein forms ion channels that are more permeable to monovalent cations than to monovalent anions. Affinity-purified polyclonal antibodies recognizing the N-terminal 19 residues of SARS-CoV E protein were used to establish the specificity of channel forination by inhibiting the ion currents generated in the presence of the E protein peptides. (C) 2004 Elsevier Inc. All rights reserved.
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