期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 101, 期 49, 页码 17033-17038出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0407902101
关键词
carbohydrate; lectin; microarray; glycoprotein; glycolipid
资金
- NIGMS NIH HHS [GM62116, U54 GM062116] Funding Source: Medline
Here we describe a glycan microarray constructed by using standard robotic microarray printing technology to couple amine functionalized glycans to an amino-reactive glass slide. The array comprises 200 synthetic and natural glycan sequences representing major glycan structures of glycoproteins and glycolipids. The array has remarkable utility for profiling the specificity of a diverse range of glycan binding proteins, including C-type lectins, siglecs, galectins, anticarbohydrate antibodies, lectins from plants and microbes, and intact viruses.
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