期刊
JOURNAL OF NEUROSCIENCE
卷 24, 期 49, 页码 11127-11136出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2933-04.2004
关键词
dendrite; two-photon; calcium; layer 2/3; up state; pyramidal neuron
Action potentials backpropagate into the dendritic trees of pyramidal neurons, reporting output activity to the sites of synaptic input and provoking long-lasting changes in synaptic strength. It is unclear how this retrograde signal is modified by neural network activity. Using whole-cell recordings from somata, apical trunks, and dendritic tuft branches of layer 2/3 pyramidal neurons in vivo, we show that network-driven subthreshold membrane depolarizations (up states) occur simultaneously throughout the apical dendritic tree. This spontaneous synaptic activity enhances action potential-evoked calcium influx into the distal apical dendrite by promoting action potential backpropagation. Hence, somatic feedback to the dendrites becomes stronger with increasing network activity.
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