期刊
CANCER LETTERS
卷 216, 期 1, 页码 21-29出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.06.001
关键词
boron; LNCaP; DU-145; PC-3; necrosis; prostate cancer
类别
资金
- NCI NIH HHS [CA-16042] Funding Source: Medline
- NIAID NIH HHS [AI-28697] Funding Source: Medline
The role of boron in biology includes coordinated regulation of gene expression in mixed bacterial populations and the growth and proliferation of higher plants and lower animals. Here we report that boric acid, the dominant form of boron in plasma, inhibits the proliferation of prostate cancer cell lines, DU-145 and LNCaP, in a dose-dependent manner. Non-tumorigenic prostate cell lines, PWR-1E and RWPE-1, and the cancer line PC-3 were also inhibited, but required concentrations higher than observed human blood levels. Studies using DU-145 cells showed that boric acid induced a cell death-independent proliferative inhibition, with little effect on cell cycle stage distribution and mitochondrial function. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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