期刊
POLYMER
卷 45, 期 26, 页码 8967-8980出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2004.10.081
关键词
micelles; amphiphilic block copolymers; poly(D,L-lactide)
Novel A-B-A triblock and star-block amphiphilic copolymers, i.e. poly(N-(2-hydroxypropyl)methacrylamide)-block-poly(D,L-lactide)block-poly(N-(2-hydroxypropyl)metha-crylamide), poly(N-vinyl-2-pyrrolidone) -block-poly(D,L-lactide)-block-poly(N-vinyl-2-pyrrolidone), star-poly(D,L-lactide)-block-poly(N-(2-hydroxypropyl)methacrylamide) and star-poly(D,L-lactide)-block-poly(N-vinylpyrrolidone), were synthesized and characterized. These polymers were prepared by free radical polymerization of N-(2-hydroxypropyl)methacrylamide and N-vinyl-2-pyrrolidone in the presence of either poly(D,L-lactide) dithiol or star-poly(D,L-lactide) tetrakis-thiol, both biodegradable macromolecular chain-transferring agents. All copolymers self-assembled in aqueous solution to form supramolecular aggregates of 20-180 nm in size. The critical aggregation concentration of the copolymers ranged from 5 to 24 mg/L, depending on their hydrophobicity. The partition equilibrium constant of pyrene in the hydrophobic core of micelles was between 0.71 x 10(5) and 1.63 x 10(5). The triblock copolymer micelles were loaded with two model poorly water-soluble drugs, namely, indomethacin (1.5-16.4% w/w) and paclitaxel (0.4-1.5% w/w), by a dialysis procedure. These triblock and star-block copolymers could prove useful as nanocarriers for the solubilization and delivery of hydrophobic drugs. (C) 2004 Elsevier Ltd. All rights reserved.
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