期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 344, 期 5, 页码 1175-1181出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2004.10.009
关键词
crystal structure; activating receptors; TREM-1; innate immunity; immune system receptor
资金
- NCI NIH HHS [CA58896] Funding Source: Medline
- NIAID NIH HHS [AI42266, T32 AI077606] Funding Source: Medline
Triggering receptor expressed on myeloid cells (TREM) I is an activating receptor expressed on myeloid cells whose ligand(s) remain elusive. TREM-1 stimulation activates neutrophils and monocytes and induces the secretion of pro-inflammatory molecules, which amplifies the Toll-like receptor-initiated responses to invading pathogens. In addition, TREM-1 mediates the septic shock pathway, and thus represents a potential therapeutic target. We report the crystal structure of the mouse TREM-1 extracellular domain at 1.76 Angstrom resolution. The mouse extracellular domain is monomeric, consistent with our previous human TREM-1 structure, and strongly supports the contention that the globular TREM-1 head is a monomer contrary to proposals of a symmetric dimer. (C) 2004 Elsevier Ltd. All rights reserved.
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