期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 101, 期 50, 页码 17545-17548出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0408242101
关键词
power law; sleep regulation; sleep fragmentation
资金
- NCRR NIH HHS [P41 RR 13622, P41 RR013622] Funding Source: Medline
- NHLBI NIH HHS [HL 071972, HL 079046, R01 HL071972, HL 02013] Funding Source: Medline
- NIMH NIH HHS [MH 39683, R01 MH062589, MH 62589] Funding Source: Medline
Although mammals of different species have different sleep patterns, brief sleep-wake transitions commonly are observed across species and appear to occur randomly throughout the sleeping period. The dynamical patterns and functions of these brief awakenings from sleep are not well understood, and they often are viewed as disruptions (random or pathologic) of the sleep process. In this article, we hypothesize that brief awakenings from sleep may reflect aspects of the endogenous sleep control mechanism and thus may exhibit certain robust dynamical patterns across species. We analyze sleep recordings from mice, rats, cats, and humans, and we compare the distributions of sleep and wake episode durations. For all four species, we find that durations of brief wake episodes during the sleep period exhibit a scale-free power-law behaviour with an exponent a that remains the same for all species (alpha approximate to 2.2). In contrast, sleep episode durations for all four species follow exponential distributions with characteristic time scales, which change across species in relation to body mass and metabolic rate. Our findings suggest common dynamical features of brief awakenings and sleep durations across species and may provide insights into the dynamics of the neural circuits controlling sleep.
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