期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 101, 期 50, 页码 17361-17364出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0408168101
关键词
computation; electrostatics; transcription
资金
- NIGMS NIH HHS [R01 GM063817, GM 63817, R01 GM063817-05, R01 GM049985, GM 49985] Funding Source: Medline
Nucleoside triphosphates (NTPs) diffuse to the active center of RNA polymerase II through a funnel-shaped opening that narrows to a negatively charged pore. Computer simulation shows that the funnel and pore reduce the rate of diffusion by a factor of approximate to2 x 10(-7). The resulting limitation on the rate of RNA synthesis under conditions of low NTP concentration may be overcome by NTP binding to an entry site adjacent to the active center. Binding to the entry site greatly enhances the lifetime of an NTP in the active center region, and it prevents backtracking and the consequent occlusion of the active site.
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