期刊
BIOSENSORS & BIOELECTRONICS
卷 20, 期 6, 页码 1083-1090出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2004.06.028
关键词
molecular imprinting; precipitation polymerisation; nanospheres; drug release; molecular recognition; theophylline
Cross-linked poly(methylnlethacrylate-co-methacrylic acid) nanospheres were imprinted with theophylline through template radical polymerisation in diluted acetonitrile solution. This study will focus on the effect of functional monomer nature used (methylmethacrylate and/or methacrylic acid) in the recognition and in the release of template in order to develop a material with combined properties of drug delivery and rebinding, for clinical applications. After template extraction the nanospheres showed satisfactory recognition properties (up to 1 mg template/g of polymer). Moreover polymers prepared selectively removed theophylline with a theophylline rebinding of 5.1 times higher than that of caffeine. a compound of similar structure. Drug release properties were also satisfactory (up to 95% of loaded theophylline in 7 days). (C) 2004 Elsevier B.V. All rights reserved.
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