期刊
JOURNAL OF INFECTIOUS DISEASES
卷 190, 期 12, 页码 2104-2108出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/425933
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资金
- NIAID NIH HHS [U54 AI057158, U54AI57158, AI51292] Funding Source: Medline
No specific vaccine for West Nile virus (WNV) is currently available for human use. In the present study, we describe the generation of WNV-like particles (WNV-LPs) in insect cells by use of recombinant baculoviruses expressing the WNV structural proteins prME or CprME. BALB/c mice immunized with purified WNV-LPs developed WNV-specific antibodies that had potent neutralizing activities. Mice immunized with prME-like particles (prME-LPs) showed no morbidity or mortality after challenge with WNV. Immunization with prME-LPs can induce sterilizing immunity without producing any evidence of viremia or viral RNA in the spleen or brain. These results suggest that WNV-LPs hold promise as a vaccine candidate for WNV infection.
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