期刊
NATURE
卷 432, 期 7019, 页码 846-854出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature03196
关键词
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资金
- NCI NIH HHS [R01 CA097061, R01 CA097061-04, R01 CA097061-01, R01 CA097061-02, R01 CA097061-03] Funding Source: Medline
Small organic molecules have proven to be invaluable tools for investigating biological systems, but there is still much to learn from their use. To discover and to use more effectively new chemical tools to understand biology, strategies are needed that allow us to systematically explore 'biological-activity space'. Such strategies involve analysing both protein binding of, and phenotypic responses to, small organic molecules. The mapping of biological-activity space using small molecules is akin to mapping the stars - uncharted territory is explored using a system of coordinates that describes where each new feature lies.
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