期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 47, 期 26, 页码 6435-6438出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm049194+
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Pathway-selective ligands for the estrogen receptor (ER) inhibit NF-kappaB-mediated inflammatory gene expression causing a reduction of cytokines, chemokines, adhesion molecules, and inflammatory enzymes. SAR development of a series of 4-(indazol-3-yl)phenols has led to the identification of WAY-169916 an orally active nonsteroidal ligand with the potential use in the treatment of rheumatoid arthritis without the classical proliferative effects associated with estrogens.
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