期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 47, 期 26, 页码 6447-6450出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm049379g
关键词
-
We describe the development of cell-permeable beta-secretase inhibitors that demonstratively inhibit the production of the secreted amino terminal fragment of an artificial amyloid precursor protein in cell culture. In addition to potent inhibition in a cell-based assay (IC50 < 100 nM), these inhibitors display impressive selectivity against other biologically relevant aspartyl proteases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据