期刊
VACCINE
卷 23, 期 5, 页码 718-728出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2004.05.031
关键词
Kenya; merozoite; epidemiology; allele specificity; subclass
Serum antibodies from 1071 people in two Kenyan villages were assayed using eight different recombinant Apical Membrane Antigen I (AMA1) protein constructs to investigate their role in naturally acquired immunity. In both communities, antibodies against the full-length ectodomain (both FVO and 3D7 allele Constructs) prior to a malaria transmission season were significantly associated with protection front malaria in the following 6 months. even after adjusting for age and antibody reactivity to whole parasite (schizont) extract. However, these protective associations of antibodies were only seen among subjects that were parasite slide positive at the time of pre-season serum sampling. Competition ELISAs with the FVO and 3D7 allele constructs showed that antibodies can recognise either conserved or allele-specific epitopes in AMA1. Results encourage the development of an AMA1 vaccine based on the full-length ectodomain. and indicate that the function of human antibodies to allele-specific and conserved epitopes in AMA1 should be studied further. (C) 2004 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据