期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 24, 页码 5997-6000出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.09.087
关键词
peptide deformylase; inhibitors; antibacterial
A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported. (C) 2004 Elsevier Ltd. All rights reserved.
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