期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 24, 页码 6057-6059出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.09.072
关键词
substituted 1,3,4-oxadiazoles; anticonvulsant; PTZ; MES
A series of new 2-substituted-5-[2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles has been synthesized and screened for their anticonvulsant activities. Compound 3 shows considerable anticonvulsant activity both in PTZ and MES models. It seems that this effect is mediated by benzodiazepine receptors and other unknown mechanism, respectively. (C) 2004 Elsevier Ltd. All rights reserved.
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