期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 69, 期 26, 页码 9025-9029出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo048789+
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资金
- NCI NIH HHS [R01CA 47135] Funding Source: Medline
Further study of the Fijian sponge Leucetta sp., a source of (+)-calcaridine A (4) and (-)spirocalcaridines A (5) and B (6), has yielded (-)-spiroleucettadine (8), the first natural product to contain a fused 2-aminoimidazole oxalane ring along with the known compounds NN-dimethylnaamidine D (3) and isonaamine B (7). NMR analysis allowed the unambiguous 2D structural assignment of 8, and its relative stereochemistry was determined by ROESY data. Good antibacterial activity was observed for 8 against Enterococcus durans with an MIC of less than 6.25 mug/mL.
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