期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
卷 359, 期 1452, 页码 1879-1882出版社
ROYAL SOC LONDON
DOI: 10.1098/rstb.2004.1556
关键词
muscle X-ray diffraction; interference; cross-bridge
类别
资金
- NCRR NIH HHS [RR08630] Funding Source: Medline
- NIAMS NIH HHS [AR43733] Funding Source: Medline
Recent studies on the interference fringes in the myosin meridional reflections provide a new source of structural information on cross-bridge movement during mechanical transients and steady shortening. Many observations can be interpreted satisfactorily by the tilting lever-arm model. with some assumptions, including the presence of fixed repeating structures contributing to the M3 and higher-order meridional reflections. In isometric contraction, the lever arms are oriented near the start of the working stroke, with a dispersion of ca +/- 20-25degrees. Upon a rapid release of 10-12 nm, they move to the end of the stroke. with a well-known T2 delay of 1-2 ms. This delay must represent additional processes. which have to occur even in tension-generating heads, or activation of attached heads, which initially do not develop force. Surprisingly. in muscles shortening at moderate loads (0.5-0.6 P-O), the mean position of the heads moves only 2-3 nm closer to the M-line than in the isometric case, reminiscent of the Piazzesi-Lombardi model.
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