In vitro studies of platelet adhesion on UV radiation-treated nylon surface

The aim of the study was to prepare a novel blood,compatible of nylon film by a-rafting O-butyrylchitosan (OBCS). The immobilization was accomplished by irradiating with ultraviolet light, OBCS being coated on the film surface to photolyze azide groups, thus crosslinking OBCS and nylon together. Surface properties of nylon were investigated by attenuated total reflection Fourier transform infrared spectroscopy, electron spectroscopy for chemical analysis and water contact angle measurements. The blood compatibility of the OBCS-grafted nylon films was evaluated by platelet rich plasma contacting experiments and the results were observed by scanning electron microscopy. The blood compatibility of OBCS grafted nylon films seems better than that of blank nylon films. The modifications could be carried out to tailor nylon biomaterial to meet the specific needs of different biomedical applications. These results suggest that the blood compatible of nylon/OBCS films make them suitable biomaterials for some applications. (C) 2004 Elsevier Ltd. All rights reserved.