Alkynylation of N-tosylimines with aryl acetylenes promoted by ZnBr2 and N,N-diisopropylethylamine in acetonitrile

We found a suitable condition for the effective alkynylation of N-tosylimines with aryl acetylenes. The reaction tosylimines and aryl acetylenes in the presence of ZnBr2, and DIEA (N,N -diisopropylethylamine) in CH3CN afforded the desired N-tosyl propargylamines in moderate to good yields. (C) 2004 Elsevier Ltd. All rights reserved.