Synthesis, crystal structures and in vitro antitumor activities of some organoantimony arylhydroxamates

A series of novel organoantimony arylhydroxamates with the formulae [Ar3SbL2,](-)[HNEt3](+) (LH = arylhydroxamic acid: Ar = C6H5. 4-CH3C6H4, 3-CH3C6H4, 4-ClC6H4, 4-FC6H4) and (4-CH3C6H4)(4)SbL were synthesized and characterized by elemental analysis, IR. H-1 NMR and mass spectroscopy. The crystal structures of (4-CH3C6H4)(4)SbL and [Ph3SbL2](-)[HNEt3](+) were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against three human cancer cells are reported. (C) 2004 Published by Elsevier B.V..