期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 288, 期 1, 页码 3-10出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2004.09.007
关键词
particle design; supercritical fluid; dissolution enhancement; micronization; nanoparticles; microspheres
In this first of two articles, we discuss some issues surrounding the dissolution rate enhancement of poorly-soluble active ingredients micronized into nano-particles using several supercritical fluid particle design processes including rapid expansion of supercritical solutions (RESS), supercritical anti-solvent (SAS) and particles from gas-saturated solutions/suspensions (PGSS). Experimental results confirm that dissolution rates do not only depend on the surface area and particle size of the processed powder, but are greatly affected by other physico-chemical characteristics such as crystal morphology and wettability that may reduce the benefit of micronization. (C) 2004 Elsevier B.V. All rights reserved.
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