期刊
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
卷 569, 期 1-2, 页码 3-11出版社
ELSEVIER
DOI: 10.1016/j.mrfmmm.2004.07.017
关键词
spontaneous mutation; RpoS; heat-shock; DNA polymerase; error-prone DNA synthesis
资金
- NIGMS NIH HHS [R01 GM065175, R01 GM065175-03, GM065175] Funding Source: Medline
Under stressful conditions mechanisms that increase genetic variation can bestow a selective advantage. Bacteria have several stress responses that provide ways in which mutation rates can be increased. These include the SOS response, the general stress, response, the heat-shock response, and the stringent response, all of which impact the regulation of error-prone polymerases. Adaptive mutation appears to be process by which cells can respond to selective pressure specifically by producing mutations. In Escherichia coli strain FC40 adaptive mutation involves the following inducible components: (i) a recombination pathway that generates mutations; (ii) a DNA polymerase that synthesizes error-containing DNA: and (iii) stress responses that regulate cellular processes. In addition, a subpopulation of cells enters into a state of hypermutation; giving rise to about 10% of the single mutants, single mutants and virtually all of the mutants with multiple mutations. These bacterial responses have implications development of cancer and other genetic disorders in higher organisms. (C) 2004 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据