Synthesis of functionalized heterocycles via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction

By combining a Staudinger/aza-Wittig and an Ugi three-cornponent reaction in a one-pot process (SAWU-3CR), a new and efficient multicomponent reaction was developed. The application of this reaction on readily available azido-aldehydes gave easy access to highly functionalized, enantiomerically pure pipecolic acid amides and bridged morpholine amide derivatives. The versatility of this methodology is demonstrated by the construction of a molecular library. (C) 2004 Elsevier Ltd. All rights reserved.