Microwave-assisted function alization of solid supports: application in the rapid loading of nucleosides on controlled-pore-glass (CPG)

Rapid and efficient functionalization of solid-support by microwave-assisted procedures has been achieved. The functionalized solid-support can be readily loaded with nucleosides for use in oligonucleotide synthesis. This method can also be extended to rapid functionalization of other solid matrices for application in microarrays and combinatorial chemistry. (C) 2004 Elsevier Ltd. All rights reserved.