期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
卷 1681, 期 2-3, 页码 175-181出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbaexp.2004.10.008
关键词
mouse tau; promoter specificity; transcriptional regulation; factors AP-2; SP-1
资金
- NINDS NIH HHS [NS38051] Funding Source: Medline
The microtubule-associated protein (MAP) tau is found primarily in neurons and errors in its regulation are associated with Alzheimer's disease and other neurodegenerative disorders. Tau expression is transcriptionally regulated and tissue-specific. In this study, starting with a similar to7500-bp fragment from the mouse tau gene, which includes tau exon -1, we define regions preferentially conferring tissue-specific expression. Furthermore, gel shift assays indicate that transcriptional regulators SP-1 and AP-2 are important for basal expression but not necessary for neuron-specific expression of the tau transcript. (C) 2004 Elsevier B.V. All rights reserved.
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