期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 53, 期 1, 页码 32-37出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf0484780
关键词
Camptotheca; camptothecin; trifolin; hyperoside; antifungal activity; chemical defense
Leaf spots and root rots are major fungal diseases in Camptotheca acuminata that limit cultivation of the plant for camptothecin (CPT), a promising anticancer and antiviral alkaloid. Bioassays showed that pure CPT and flavonoids (trifolin and hyperoside) isolated from Camptotheca effectively control fungal pathogens in vitro, including Alternaria alternata, Epicoccum nigrum, Pestalotia guepinii, Drechslera sp., and Fusarium avenaceum, although antifungal activity of these compounds in the plant is limited. CPT inhibited mycelial growth by approximately 50% (EC50) at 10-30 mug/mL and fully inhibited growth at 75-125 mug/mL. The flavonoids were less effective than CPT at 50 mug/mL, particularly within 20 days after treatment, but more effective at 100 or 150 mug/mL. CPT, trifolin, and hyperoside may serve as leads for the development of fungicides.
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