期刊
NEUROIMAGE
卷 24, 期 2, 页码 591-595出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2004.09.034
关键词
ischemic stroke; peripheral benzodiazepine binding site; activated microglia; [C-11](R)-PK11195 PET
We obtained [C-11](R)-PK11195 PET scans in six patients at different time points between 3 and 150 days after onset of ischemic stroke in order to measure the time course of microglial activation. Increased [C-11](R)-PK11195 binding around the lesion was observed as early as 3 days. Scans at later time points showed ongoing changes in the distribution of the [C-11](R)-PK11195 signal, involving the area of the primary lesion and areas distant from the primary lesion site. Our data suggest that [C-11](R)-PK11195 PET can be used to investigate both the primary lesion and remote pathological changes following Wallerian degeneration. (C) 2004 Elsevier Inc. All rights reserved.
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