期刊
BIOLOGICAL PSYCHIATRY
卷 57, 期 2, 页码 139-144出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2004.10.018
关键词
association; catechol-O-methyltransferase; meta-analysis; schizophrenia
Background: A common functional polymorphism (Val/Met) in the catechol-O-methyltransferse gene (COMT) that markedly affects enzyme activity has been shown to affect executive cognition and the physiology of the prefrontal cortex in humans. It is hypothesized that the high activity Val allele slightly increases risk for schizophrenia through its effect on dopamine-mediated prefrontal information processing. Methods: We compared the allele/genotype frequencies of the Val/Met polymorphisms in a large independent patient-control sample (862 patient and 928 healthy control subjects) from Han Chinese population, and an update meta-analysis was performed to assess the collective evidence across individual studies. Results: No statistically significant differences were found ina llele or genotype frequencies between patient and normal control subjects, although a nonsignificant overrepresentation of the Val allele in schizophrenia patients (odds ratio [OR] = 1.09 95% confidence interval [CI] = .94-1.26) was suggested . Comparatively, the meta-analysis of all published population-based association studies showed statistically significant evidence for heterogeneity among the group of studies. Stratification of the studies by ethnicity of the samples yielded no significant evidence for an association with the Val allele in Asian population (OR = .96, 95% CI = .85-1.09), nor in European population (OR = 1.06, 95% CI = .95-1.19). Conclusions: Our data provide minimal evidence that the Val allele is a susceptibility factor for schizophrenia in either European or Asian populations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据