期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 562, 期 2, 页码 629-634出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1113/jphysiol.2004.075747
关键词
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资金
- NHLBI NIH HHS [R01 HL061388-03, R01 HL061388-06, HL 67422, R01 HL061388-02, R01 HL061388-01, R01 HL067422, R01 HL061388-05A1, R01 HL061388-08, R01 HL061388, HL 61388, R01 HL061388-04, R01 HL061388-07] Funding Source: Medline
- NIGMS NIH HHS [GM 68865, R01 GM068865] Funding Source: Medline
Two experiments were performed to identify whether nitric oxide (NO) inhibits sympathetically mediated vasoconstriction in human skin. In eight subjects increasing doses of sodium nitroprusside (SNP; 8.4 x 10(-6) -8.4 x 10(-3) m) were administered via intradermal microdialysis. At each dose of SNP, cutaneous vasoconstrictor responsiveness was assessed during a 3 min whole-body cold stress. The relative reduction in forearm cutaneous vascular conductance (CVC) during the cold stress was significantly attenuated for SNP doses greater than 8.4 x 10(-4) M (control: 63.0 +/- 4.1%, SNP 8.4 x 10(-6) M: 57.1 +/- 4.7%, SNP 8.4 x 10(-5) M: 57.0 +/- 3.6%, SNP 8.4 x 10(-4) M: 44.5 +/- 5.4% and SNP 8.4 x 10(-3) M: 28.8 +/- 7.9%). The second experiment was performed to identify whether this response was due to NO attenuating sympathetically mediated vasoconstriction or due to a non-specific effect of an elevated CVC secondary to SNP administration. In seven subjects forearm CVC during a whole-body cold stress was assessed at two sites: at a site dilated via microdialysis administration of SNP and at a site dilated with isoproterenol (ISO). CVC was not different between sites prior to (SNP: 0.42 +/- 0.11; ISO: 0.46 +/- 0.11 AU mmHg(-1) (AU, arbitrary units), P > 0.05) or following drug infusion (SNP: 1.36 +/- 0.21; ISO: 1.27 +/- 0.23 AU mmHg(-1), P > 0.05). The reduction in CVC during the subsequent cold stress was significantly less at the SNP site (38.1 +/- 6.2%) relative to the ISO site (65.0 +/- 5.5%; P = 0.007). These data suggest NO is capable of inhibiting sympathetically mediated vasoconstriction in the cutaneous vasculature.
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